SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION AND SCHIFF BASES N1, N3-DI (E)-BENZYLIDENE MONOHYDRIDE DERIVATIVES

Abstract

Schiff bases and their derivatives have attracted considerable attention in recent years due to their versatile applications in medicinal, pharmaceutical, and coordination chemistry. These compounds, typically formed through the condensation of primary amines with aldehydes or ketones, are known for their broad spectrum of biological activities, including antimicrobial, antifungal, anticancer, and anti-inflammatory properties. In the present study, the synthesis, structural characterization, and spectroscopic analysis of N1, N3-di(E)-benzylidene monohydrazide Schiff base derivatives were carried out to explore their potential utility in pharmaceutical chemistry. The synthesis was achieved via a condensation reaction between aromatic aldehydes and a dihydrazide precursor under mild reaction conditions, yielding the desired Schiff bases in good yields. The structures of the synthesized compounds were elucidated using a comprehensive suite of analytical techniques. Fourier-transform infrared spectroscopy (FTIR) confirmed the formation of the imine (C=N) functional group, a key characteristic of Schiff bases. Proton nuclear magnetic resonance (^1H NMR) and carbon-13 nuclear magnetic resonance (^13C NMR) spectroscopy provided detailed insights into the chemical environment of the hydrogen and carbon atoms, respectively, supporting the proposed molecular structures. Additionally, mass spectrometry was employed to verify the molecular weights and further corroborate the identity of the synthesized derivatives. The study contributes valuable structural information and confirms the successful synthesis of these novel Schiff base compounds. Given their established biological relevance and the structural diversity offered by the benzylidene and hydrazide moieties, the synthesized derivatives present promising candidates for further pharmacological evaluation. Future work will focus on investigating the biological activities of these compounds, with an emphasis on their antimicrobial and anticancer potential. Overall, this research underscores the significance of Schiff bases in drug discovery and their continued importance in medicinal chemistry.