Therapeutic Hypolipidemic Activity Of Traditional Polyherbal Formulations

Abstract

Hyperlipidemia, particularly elevated low-density lipoprotein (LDL) cholesterol, is a major risk factor for atherosclerosis and cardiovascular diseases, which
remain the leading cause of global mortality. Although several synthetic antihyperlipidemic drugs are available, their long-term use is often associated with adverse
effects and limited patient compliance. This review aims to provide a comprehensive overview of traditional polyherbal formulations used in the management of
hyperlipidemia, with a focus on their phytoconstituents, therapeutic potential, and mechanisms of action.
Relevant literature was collected from scientific databases including PubMed, Scopus, and Web of Science, focusing on studies related to polyherbal formulations
with antihyperlipidemic activity. Various traditional formulations such as Arogyavardhini vati, Navaka Guggulu, and formulations containing Trigonella foenumgraecum, Ziziphus lotus, and Commiphora wightii have demonstrated significant lipid-lowering effects. These formulations act through multiple mechanisms,
including inhibition of HMG-CoA reductase, antioxidant activity, and modulation of lipid metabolism pathways. Polyherbal formulations represent a promising
alternative to conventional therapies due to their multi-targeted action, natural origin, and relatively lower side effects. However, further standardization, clinical
validation, and mechanistic studies are required to establish their safety, efficacy, and global acceptance.
Hyperlipidemia, Polyherbal formulations, Antihyperlipidemic activity, Medicinal plants, Lipid metabolism