Formulation and Evaluation of ZnO-loaded levofloxacin nanoparticles to fight Salmonella typhi

Abstract

Nanomaterials containing inorganic metallic ions are commonly employed to treat various illnesses, including cancer, autoimmune disorders, and bacterial and fungal colonization. In this study, Zn-loaded levofloxacin nanoparticles (ZLFNs) are used as an antibacterial agent. The adsorption-produced nanocarriers were examined using FTIR, SEM, TEM, and HPLC. Simulated body fluid was used in in vitro release experiments at 37 °C. Data were evaluated using a variety of kinetic models, which revealed a slow dissolution for 12 to 24 hours. Research on antimicrobial agents revealed enhanced efficaciousness against Salmonella typhi. It was experimentally found that ZLFNs possessed a particle size of 140.1 nm with a zeta potential value of -19.8 mV and had a good encapsulation efficiency of 87-91%.