HEMOCOMPATIBILITY OF CELLULOSE-CHITOSAN COATED FOR ORTHOPAEDIC APPLICATION

Abstract

Biodegradable magnesium (Mg) alloys have gained significant attention in orthopaedic applications because of their biocompatibility and controlled degradation
properties. The present study evaluated the hemocompatibility of cellulose–chitosan (CC) coated Mg alloy for biomedical implant applications. Chitosan solution
prepared using acetic acid was combined with cellulose solution to obtain a homogeneous coating mixture. The Mg alloy surface was polished, coated with the
CC solution, and dried at room temperature. Surface morphology, hemolytic activity, Fourier transform infrared spectroscopy (FTIR), and biomineralization studies
were performed. SEM analysis revealed petal-like surface morphology with interconnected structures. The hemolysis rate of the coated sample was below 5 %,
indicating non-hemolytic behavior according to ASTM standards. FTIR confirmed the presence of hydroxyl, amide, and carboxyl functional groups.
Biomineralization studies demonstrated calcium and phosphate deposition on the coated surface. The results suggest that CC-coated Mg alloy possesses good
hemocompatibility and biomineralization potential for orthopaedic implant applications.