Study of the toxic effects of tertrazine on some functional parameters in albino rats

Abstract

Objective: The present study aims to investigate the adverse effects of tartrazine dye on various functional parameters in laboratory albino rats Rattus norvegicus.
The present study was conducted from September (2024) to November (2024) at the University of Karbala / College of Education for Pure Sciences / Department
of Life Sciences / Graduate Laboratory. (12) Adult male albino rats were used in this experiment, with weights ranging from 190 to 230 grams and ages ranging
from 11 to 13 weeks. They were systematically classified into two groups, each containing six animals. The initial group (G1) served as a negative control, as it
received unrestricted access to water and feed, while the subsequent group (G2) served as a positive control, as it was given an aqueous solution of tartrazine at a
dose of 400 mg/kg of total body weight. After the end of the test period (30 days), the animals were anesthetized with chloroform in a closed manner, blood was
drawn directly from the heart, and tests were performed for the studied functional parameters. The results indicated a significant increase (P≤0.05) in the
concentrations of liver enzymes (ALP, ALT, AST) and kidney parameters including urea and creatinine, in addition to a decrease in antioxidant levels (SOD, GSH,
CAT), an increase in malondialdehyde (MDA), an increase in lipid concentrations (LDL, TC, TG) and a decrease in (HDL) when comparing group (G2) with
group (G1).