Reproductive Outcome After Hystroscopic Metroplasty for Septate Uterus: Systematic Review

Abstract

Background: Still the effectiveness and safety of hystroscopic metroplasty in managing septate uterus is questionnable as the current evidence of whether it improves
reproductive outcomes is inconsistent.
Objective: To summarize the reproductive outcomes after hystroscopic metroplasty in women with septate uterus as well as to investigate whether pregnancy was
normal or after in-vito fertilization among those women.
Material and methods: A systematic review has been implemented according to the guidelines of the Preferred Reporting Items for Systematic
Reviews and Meta-analyses (PRISMA) utilizing PubMed-MEDLINE, EMBASE, Google Scholar, Web of Science, The Cochrane Library and
the Gynaecology and Fertility (CGF) Specialized Register of Controlled Trials electronic databases. Eligible studies were those including women diagnosed with
either complete or partial septate uterus and managed by hystroscopic metroplasty versus no or other interventions (control subjects).
Results: A the final step, 12 studies with 1471 women diagnosed with septate uterus (partial/complete) were included in the present review.
Miscarriage was reduced after hystroscopic metroplasty according to several studies while no significant differences were observed as regards
the terms of live births and preterm labour between patients with hysteroscopic metroplasty and those who had no intervention as indicated by
some studies.
Conclusion: Hysteroscopic metroplasty is of beneficial effect in reducing the risk of miscarriage and increase the rate of conception in women
with septate uterus. However, larger, prospective trials before further made clinical decisions regarding the value of hysteroscopic septum
resection are recommended.